Indeterminate nodules in osteosarcoma: what's the follow-up?

ABSTRACT:

Background

Indeterminate pulmonary nodules in patients diagnosed with osteosarcoma present a challenge for accurate staging and prognosis. The aim of this study was to explore the significance of this finding.

Methods

A retrospective cohort study of 120 patients with osteosarcoma was performed in the North East of England. Chest computed tomographies (CTs) at presentation were reviewed and the incidence of 'indeterminate' nodules recorded. Follow-up scans were reviewed and survival as well as prognostic features were analysed.

Results

25% of our cohort presented with indeterminate nodules. Of these, 33% were subsequently confirmed as metastases, the majority within a year. Kaplan-Meier survival analysis showed that patients with indeterminate nodules fared better than

SUBMITTER: Ghosh KM 

PROVIDER: S-EPMC5846065 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature