Magnetic resonance spectroscopy reveals abnormalities of glucose metabolism in the Alzheimer's brain.

ABSTRACT:

Objective

Brain glucose hypometabolism is a prominent feature of Alzheimer's disease (AD), and in this case-control study we used Magnetic Resonance Spectroscopy (MRS) to assess AD-related differences in the posterior cingulate/precuneal ratio of glucose, lactate, and other metabolites.

Methods

J-modulated Point-Resolved Spectroscopy (J-PRESS) and Prior-Knowledge Fitting (ProFit) software was used to measure glucose and other metabolites in the posterior cingulate/precuneus of 25 AD, 27 older controls, and 27 younger control participants. Clinical assessments for AD participants included cognitive performance measures, insulin resistance metrics and CSF biomarkers.

Results

AD participants showed substantially elevated glucose, lactate, and ascorbate levels compared to

SUBMITTER: Mullins R 

PROVIDER: S-EPMC5846391 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature