Inflammatory mediator expression within retrieved clots in acute ischemic stroke.

ABSTRACT:

Objective

In this study we investigate the association between the expression of inflammatory mediators measured in clots retrieved by mechanical thrombectomy, stroke etiology, and the susceptibility vessel sign (SVS) on gradient-echo (GRE) MR imaging in acute ischemic stroke patients.

Methods

We performed molecular analysis of intracranial clots retrieved by mechanical thrombectomy from 82 patients with acute stroke. Seventy-two of these patients underwent GRE imaging before endovascular therapy. We measured the relative expression of inflammatory mediators by performing the quantitative real-time polymerase chain reaction on the retrieved clots and assessed associations between the expression of inflammatory mediators and stroke subtypes as well as with GRE SVS.

Results

SUBMITTER: Baek BH 

PROVIDER: S-EPMC5846392 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature