Regeneration of Tracheal Tissue in Partial Defects Using Porcine Small Intestinal Submucosa.

ABSTRACT:

Background

Surgical correction of tracheal defects is a complex procedure when the gold standard treatment with primary end-to-end anastomosis is not possible. An alternative treatment may be the use of porcine small intestinal submucosa (SIS). It has been used as graft material for bioengineering applications and to promote tissue regeneration. The aim of this study was to evaluate whether SIS grafts improved tracheal tissue regeneration in a rabbit model of experimental tracheostomy.

Methods

Sixteen rabbits were randomized into two groups. Animals in the control group underwent only surgical tracheostomy, while animals in the SIS group underwent surgical tracheostomy with an SIS graft covering the defect. We examined tissues at the site of tracheostomy 60 days after surger

SUBMITTER: Bergonse Neto N 

PROVIDER: S-EPMC5846444 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature