Recommendations for Laboratory Containment and Management of Gene Drive Systems in Arthropods.

ABSTRACT: Versatile molecular tools for creating driving transgenes and other invasive genetic factors present regulatory, ethical, and environmental challenges that should be addressed to ensure their safe use. In this article, we discuss driving transgenes and invasive genetic factors that can potentially spread after their introduction into a small proportion of individuals in a population. The potential of invasive genetic factors to increase their number in natural populations presents challenges that require additional safety measures not provided by previous recommendations regarding accidental release of arthropods. In addition to providing physical containment, invasive genetic factors require greater attention to strain management, including their distribution and identity confirmation. In

SUBMITTER: Benedict MQ 

PROVIDER: S-EPMC5846571 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature