Balanced Crystalloids versus Saline in Noncritically Ill Adults.

ABSTRACT:

Background

Comparative clinical effects of balanced crystalloids and saline are uncertain, particularly in noncritically ill patients cared for outside an intensive care unit (ICU).

Methods

We conducted a single-center, pragmatic, multiple-crossover trial comparing balanced crystalloids (lactated Ringer's solution or Plasma-Lyte A) with saline among adults who were treated with intravenous crystalloids in the emergency department and were subsequently hospitalized outside an ICU. The type of crystalloid that was administered in the emergency department was assigned to each patient on the basis of calendar month, with the entire emergency department crossing over between balanced crystalloids and saline monthly during the 16-month trial. The primary outcome was hospital-free

SUBMITTER: Self WH 

PROVIDER: S-EPMC5846618 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature