'Molecular habituation' as a potential mechanism of gradual homeostatic loss with age.

ABSTRACT: The ability of reactive oxygen species (ROS) to cause molecular damage has meant that chronic oxidative stress has been mostly studied from the point of view of being a source of toxicity to the cell. However, the known duality of ROS molecules as both damaging agents and cellular redox signals implies another perspective in the study of sustained oxidative stress. This is a perspective of studying oxidative stress as a constitutive signal within the cell. In this work, we adopt a theoretical perspective as an exploratory and explanatory approach to examine how chronic oxidative stress can interfere with signal processing by redox signalling pathways in the cell. We report that constitutive signals can give rise to a 'molecular habituation' effect that can prime for a gradual loss of biolo

SUBMITTER: Martinez Guimera A 

PROVIDER: S-EPMC5846846 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature