Longitudinal investigation of neuroinflammation and metabolite profiles in the APP_swe ×PS1_Δe9 transgenic mouse model of Alzheimer's disease.

ABSTRACT: There is increasing evidence linking neuroinflammation to many neurological disorders including Alzheimer's disease (AD); however, its exact contribution to disease manifestation and/or progression is poorly understood. Therefore, there is a need to investigate neuroinflammation in both health and disease. Here, we investigate cognitive decline, neuroinflammatory and other pathophysiological changes in the APP_swe ×PS1_Δe9 transgenic mouse model of AD. Transgenic (TG) mice were compared to C57BL/6 wild type (WT) mice at 6, 12 and 18 months of age. Neuroinflammation was investigated by [¹⁸ F]DPA-714 positron emission tomography and myo-inositol levels using ¹ H magnetic resonance spectroscopy (MRS) in vivo. Neuronal and cellular dysfunction was inve

SUBMITTER: Chaney A 

PROVIDER: S-EPMC5846890 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature