Evolution of Synonymous Codon Usage Bias in West African and Central African Strains of Monkeypox Virus.

ABSTRACT: The evolution of bias in synonymous codon usage in chosen monkeypox viral genomes and the factors influencing its diversification have not been reported so far. In this study, various trends associated with synonymous codon usage in chosen monkeypox viral genomes were investigated, and the results are reported. Identification of factors that influence codon usage in chosen monkeypox viral genomes was done using various codon usage indices, such as the relative synonymous codon usage, the effective number of codons, and the codon adaptation index. The Spearman rank correlation analysis and a correspondence analysis were used for correlating various factors with codon usage. The results revealed that mutational pressure due to compositional constraints, gene expression level, and selection a

SUBMITTER: Karumathil S 

PROVIDER: S-EPMC5846927 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature