Prolonged-Release Fampridine as Adjunct Therapy to Active Motor Training in MS Patients: A Pilot, Double-Blind, Randomized, Placebo-Controlled Study.

ABSTRACT:

Background

Both prolonged-release fampridine (PRF) and enabling active motor training (EAMT) are beneficial in multiple sclerosis (MS) patients. Their combined effect is, however, understudied.

Objective

The objective of this paper is to determine if PRF augments the beneficial effect of EAMT in MS patients as opposed to placebo.

Method

This is a pilot, randomized, placebo-controlled, double-blind 14-week study. Participants were randomly assigned to receive PRF 10 mg BID (n = 21) or placebo (n = 20). All patients underwent EAMT during the first six weeks. Patients were assessed at -4, 0, 6 and 14 weeks.

Results

Both groups remained stable between -4 to 0 weeks and showed statistically significant improvements for the six-minute walk and the five-

SUBMITTER: Jacques F 

PROVIDER: S-EPMC5846958 | biostudies-literature | 2018 Jan-Mar

REPOSITORIES: biostudies-literature