Raptor localization predicts prognosis and tamoxifen response in estrogen receptor-positive breast cancer.

ABSTRACT:

Purpose

Deregulated PI3K/mTOR signals can promote the growth of breast cancer and contribute to endocrine treatment resistance. This report aims to investigate raptor and its intracellular localization to further understand its role in ER-positive breast cancer.

Methods

Raptor protein expression was evaluated by immunohistochemistry in 756 primary breast tumors from postmenopausal patients randomized to tamoxifen or no tamoxifen. In vitro, the MCF7 breast cancer cell line and tamoxifen-resistant MCF7 cells were studied to track the raptor signaling changes upon resistance, and raptor localization in ERα-positive cell lines was compared with that in ERα-negative cell lines.

Results

Raptor protein expression in the nucleus was high in ER/PgR-positive and HER2-negative t

SUBMITTER: Bostner J 

PROVIDER: S-EPMC5847064 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature