Adjunctive Oral Voriconazole Treatment of Fusarium Keratitis: A Secondary Analysis From the Mycotic Ulcer Treatment Trial II.

ABSTRACT:

Importance

Fusarium keratitis is common and often results in poor outcomes. No new treatments since natamycin have become available.

Objective

To explore the role of adjuvant oral voriconazole on clinical outcomes in Fusarium keratitis.

Design, setting, and participants

In this prespecified subgroup analysis of a multicenter, double-masked, placebo-controlled randomized clinical trial, 240 patients from the Aravind Eye Care System in India, the Lumbini Eye Hospital and Bharatpur Eye Hospital in Nepal, and the University of California, San Francisco, who had culture-positive fungal ulcer and baseline visual acuity of 20/400 or worse were randomized to receive oral voriconazole vs placebo. Enrollment started May 24, 2010, and the last patient study visit was November 23

SUBMITTER: Prajna NV 

PROVIDER: S-EPMC5847083 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature