Two microRNA signatures for malignancy and immune infiltration predict overall survival in advanced epithelial ovarian cancer.

ABSTRACT: MicroRNAs have been established as key regulators of tumor gene expression and as prime biomarker candidates for clinical phenotypes in epithelial ovarian cancer (EOC). We analyzed the coexpression and regulatory structure of microRNAs and their co-localized gene targets in primary tumor tissue of 20 patients with advanced EOC in order to construct a regulatory signature for clinical prognosis. We performed an integrative analysis to identify two prognostic microRNA/mRNA coexpression modules, each enriched for consistent biological functions. One module, enriched for malignancy-related functions, was found to be upregulated in malignant versus benign samples. The second module, enriched for immune-related functions, was strongly correlated with imputed intratumoral immune infiltrates of T

SUBMITTER: Korsunsky I 

PROVIDER: S-EPMC5847100 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature