Predictive accuracy of combined genetic and environmental risk scores.

ABSTRACT: The substantial heritability of most complex diseases suggests that genetic data could provide useful risk prediction. To date the performance of genetic risk scores has fallen short of the potential implied by heritability, but this can be explained by insufficient sample sizes for estimating highly polygenic models. When risk predictors already exist based on environment or lifestyle, two key questions are to what extent can they be improved by adding genetic information, and what is the ultimate potential of combined genetic and environmental risk scores? Here, we extend previous work on the predictive accuracy of polygenic scores to allow for an environmental score that may be correlated with the polygenic score, for example when the environmental factors mediate the genetic risk. We d

SUBMITTER: Dudbridge F 

PROVIDER: S-EPMC5847122 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature