Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis.

ABSTRACT: Interneurons navigate along multiple tangential paths to settle into appropriate cortical layers. They undergo a saltatory migration paced by intermittent nuclear jumps whose regulation relies on interplay between extracellular cues and genetic-encoded information. It remains unclear how cycles of pause and movement are coordinated at the molecular level. Post-translational modification of proteins contributes to cell migration regulation. The present study uncovers that carboxypeptidase 1, which promotes post-translational protein deglutamylation, controls the pausing of migrating cortical interneurons. Moreover, we demonstrate that pausing during migration attenuates movement simultaneity at the population level, thereby controlling the flow of interneurons invading the cortex. Interferi

SUBMITTER: Silva CG 

PROVIDER: S-EPMC5847171 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature