The identification of celiac disease in asymptomatic children: the Generation R Study.

ABSTRACT:

Background

The objective of our study was to assess whether TG2A levels in the healthy childhood population can be predictive of subclinical CD.

Methods

A total of 4442 children (median age, 6.0 years) participating in a population-based prospective cohort study were screened on serum TG2A. Those with positive TG2A (≥7 U/ml; n = 60, 1.4%) were invited for clinical evaluation (median age, 9.0 years). Medical history, physical examination, serum TG2A, and IgA-endomysium (EMA) were assessed, as well as HLA DQ 2.2/2.5/8 typing. Patients with positive serologies and genetic risk types underwent duodenal biopsies. TG2A levels at the time of biopsy were compared with the degree of enteropathy.

Results

Fifty-one TG2A-positive children were included in the follow-up: 31 (60.8%

SUBMITTER: Jansen M 

PROVIDER: S-EPMC5847176 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature