Prolonging herd immunity to cholera via vaccination: Accounting for human mobility and waning vaccine effects.

ABSTRACT:

Background

Oral cholera vaccination is an approach to preventing outbreaks in at-risk settings and controlling cholera in endemic settings. However, vaccine-derived herd immunity may be short-lived due to interactions between human mobility and imperfect or waning vaccine efficacy. As the supply and utilization of oral cholera vaccines grows, critical questions related to herd immunity are emerging, including: who should be targeted; when should revaccination be performed; and why have cholera outbreaks occurred in recently vaccinated populations?

Methods and findings

We use mathematical models to simulate routine and mass oral cholera vaccination in populations with varying degrees of migration, transmission intensity, and vaccine coverage. We show that migration and waning

SUBMITTER: Peak CM 

PROVIDER: S-EPMC5847240 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature