Intranasal delivery of stem cell-based therapies for the treatment of brain malignancies.

ABSTRACT:

Introduction

Glioblastoma (GBM) is the most aggressive malignant brain cancer in adults, and its poor prognosis and resistance to the existing standard of care require the development of innovative therapeutic modalities. The local delivery of stem cells as therapeutic carriers against glioma has produced encouraging results, but encounters obstacles with regards to the repeatability and invasiveness of administration. Intranasal delivery of therapeutic stem cells could overcome these obstacles, among others, as a noninvasive and easily repeatable mode of administration.

Areas covered

This review describes nasal anatomy, routes of stem cell migration, and factors affecting stem cell delivery to hard-to-reach tumors. Furthermore, this review discusses the molecular mechanisms

SUBMITTER: Li G 

PROVIDER: S-EPMC5847369 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature