Magnetically Guided Self-Assembly and Coding of 3D Living Architectures.

ABSTRACT: In nature, cells self-assemble at the microscale into complex functional configurations. This mechanism is increasingly exploited to assemble biofidelic biological systems in vitro. However, precise coding of 3D multicellular living materials is challenging due to their architectural complexity and spatiotemporal heterogeneity. Therefore, there is an unmet need for an effective assembly method with deterministic control on the biomanufacturing of functional living systems, which can be used to model physiological and pathological behavior. Here, a universal system is presented for 3D assembly and coding of cells into complex living architectures. In this system, a gadolinium-based nonionic paramagnetic agent is used in conjunction with magnetic fields to levitate and assemble cells. Thus,

SUBMITTER: Tocchio A 

PROVIDER: S-EPMC5847371 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature