Striatal dopamine D1-type receptor availability: no difference from control but association with cortical thickness in methamphetamine users.

ABSTRACT: Chronic methamphetamine use poses potentially devastating consequences for directly affected individuals and for society. Lower dopamine D2-type receptor availability has been observed in striata of methamphetamine users as compared with controls, but an analogous comparison of D1-type receptors has been conducted only on post-mortem material, with no differences in methamphetamine users from controls in the caudate nucleus and putamen and higher D1-receptor density in the nucleus accumbens. Released from neurons when methamphetamine is self-administered, dopamine binds to both D1- and D2-type receptors in the striatum, with downstream effects on cortical activity. Thus, both receptor subtypes may contribute to methamphetamine-induced alterations in cortical morphology and behavior. In thi

SUBMITTER: Okita K 

PROVIDER: S-EPMC5847392 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature