Integration of Contact Tracing and Phylogenetics in an Investigation of Acute HIV Infection.

ABSTRACT:

Background

The integration of traditional contact tracing with HIV sequence analyses offers opportunities to mitigate some of the barriers to effective network construction. We used combined analyses during an outbreak investigation of spatiotemporally clustered acute HIV infections to evaluate if the observed clustering was the product of a single outbreak.

Methods

We investigated acute and recent HIV index cases reported in North Carolina from 2013 to 2014 and their reported contacts. Contact tracing networks were constructed with surveillance data and compared with phylogenetic transmission clusters involving an index case using available HIV-1 pol sequences including 1672 references. Clusters were defined as clades of 2 or more sequences with a less than 1.5% genetic dis

SUBMITTER: Dennis AM 

PROVIDER: S-EPMC5847418 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature