Diminished medial prefrontal cortex activation during the recollection of stressful events is an acquired characteristic of PTSD.

ABSTRACT:

Background

Previous research has shown relatively diminished medial prefrontal cortex activation and heightened psychophysiological responses during the recollection of personal events in post-traumatic stress disorder (PTSD), but the origin of these abnormalities is unknown. Twin studies provide the opportunity to determine whether such abnormalities reflect familial vulnerabilities, result from trauma exposure, or are acquired characteristics of PTSD.

Methods

In this case-control twin study, 26 male identical twin pairs (12 PTSD; 14 non-PTSD) discordant for PTSD and combat exposure recalled and imagined trauma-unrelated stressful and neutral life events using a standard script-driven imagery paradigm during functional magnetic resonance imaging and concurrent skin conducta

SUBMITTER: Dahlgren MK 

PROVIDER: S-EPMC5847462 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature