Abnormal fronto-striatal activation as a marker of threshold and subthreshold Bulimia Nervosa.

ABSTRACT: This study aimed to determine whether functional disturbances in fronto-striatal control circuits characterize adolescents with Bulimia Nervosa (BN) spectrum eating disorders regardless of clinical severity. FMRI was used to assess conflict-related brain activations during performance of a Simon task in two samples of adolescents with BN symptoms compared with healthy adolescents. The BN samples differed in the severity of their clinical presentation, illness duration and age. Multi-voxel pattern analyses (MVPAs) based on machine learning were used to determine whether patterns of fronto-striatal activation characterized adolescents with BN spectrum disorders regardless of clinical severity, and whether accurate classification of less symptomatic adolescents (subthreshold BN; SBN) could be

SUBMITTER: Cyr M 

PROVIDER: S-EPMC5847471 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature