Large-scale computational drug repositioning to find treatments for rare diseases.

ABSTRACT: Rare, or orphan, diseases are conditions afflicting a small subset of people in a population. Although these disorders collectively pose significant health care problems, drug companies require government incentives to develop drugs for rare diseases due to extremely limited individual markets. Computer-aided drug repositioning, i.e., finding new indications for existing drugs, is a cheaper and faster alternative to traditional drug discovery offering a promising venue for orphan drug research. Structure-based matching of drug-binding pockets is among the most promising computational techniques to inform drug repositioning. In order to find new targets for known drugs ultimately leading to drug repositioning, we recently developed eMatchSite, a new computer program to compare drug-b

SUBMITTER: Govindaraj RG 

PROVIDER: S-EPMC5847522 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature