Transcriptional landscape of human endogenous retroviruses (HERVs) and other repetitive elements in psoriatic skin.

ABSTRACT: Human endogenous retrovirus (HERV) sequences make up at least 8% of the human genome. Transcripts originating from these loci as well as proteins encoded by them have been detected in various tissues. HERVs are believed to be implicated in autoimmune diseases, however the extent to which, has remained unclear. Differential expression studies have so far been limited to certain HERV subfamilies with conserved sequences. No studies have been published describing the genome-wide expression pattern of HERVs and repetitive elements in the context of psoriasis. In the present study, we analysed total RNA sequencing data from skin samples of 12 psoriasis patients and 12 healthy controls, which enabled us to describe the entire transcriptional landscape of repetitive elements. We report high level

SUBMITTER: Lattekivi F 

PROVIDER: S-EPMC5847543 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature