The mitochondrial ATP synthase is a shared drug target for aging and dementia.

ABSTRACT: Aging is a major driving force underlying dementia, such as that caused by Alzheimer's disease (AD). While the idea of targeting aging as a therapeutic strategy is not new, it remains unclear how closely aging and age-associated diseases are coupled at the molecular level. Here, we discover a novel molecular link between aging and dementia through the identification of the molecular target for the AD drug candidate J147. J147 was developed using a series of phenotypic screening assays mimicking disease toxicities associated with the aging brain. We have previously demonstrated the therapeutic efficacy of J147 in several mouse models of AD. Here, we identify the mitochondrial α-F₁ -ATP synthase (ATP5A) as a target for J147. By targeting ATP synthase, J147 causes an increase in in

SUBMITTER: Goldberg J 

PROVIDER: S-EPMC5847861 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature