T-cell Immunoglobulin and ITIM Domain Contributes to CD8⁺ T-cell Immunosenescence.

ABSTRACT: Aging is associated with immune dysfunction, especially T-cell defects, which result in increased susceptibility to various diseases. Previous studies showed that T cells from aged mice express multiple inhibitory receptors, providing evidence of the relationship between T-cell exhaustion and T-cell senescence. In this study, we showed that T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain (TIGIT), a novel co-inhibitory receptor, was upregulated in CD8⁺ T cells of elderly adults. Aged TIGIT⁺ CD8⁺ T cells expressed high levels of other inhibitory receptors including PD-1 and exhibited features of exhaustion such as downregulation of the key costimulatory receptor CD28, representative intrinsic transcriptional regulation,

SUBMITTER: Song Y 

PROVIDER: S-EPMC5847879 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature