Serum proton NMR metabolomics analysis of human lung cancer following microwave ablation.

ABSTRACT:

Background

To find potential serum biomarkers of microwave ablation (MWA) for treatment of human lung cancer by ¹H nuclear magnetic resonance (NMR)-based metabolomics analysis.

Methods

Serum specimens collected from 43 healthy individuals, 39 patients with advanced non-small cell lung cancer (NSCLC) and 38 NSCLC patients treated with MWA, were subjected to ¹H NMR-based metabolomics analysis. Partial least squares discriminant analysis was used to analyze the data.

Results

Compared with healthy controls, NSCLC patients showed significantly elevated serum levels of lactate, alanine, glutamate, proline, glycoprotein, phenylalanine, tyrosine and tryptophan, and markedly decreased serum levels of glucose, taurine, glutamine, glycine, phosphocreatine a

SUBMITTER: Hu JM 

PROVIDER: S-EPMC5848604 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature