Longitudinal Viral Dynamics in Semen During Early HIV Infection.

ABSTRACT:

Background

Multiple viruses coinfect the male genital tract, influencing each other’s replication and perhaps affecting human immunodeficiency virus (HIV) pathogenesis and disease progression.

Methods

This study included 453 longitudinal seminal samples from 195 HIV-infected men from the San Diego Primary Infection Resource Consortium and 67 seminal samples from HIV-negative healthy controls. Seminal HIV RNA and DNA from 7 human herpesviruses (HHVs) were measured by real-time polymerase chain reaction. Longitudinal shedding rates were determined by Kaplan-Meier survival analysis. Predictors of viral shedding were determined using backwards selection in a multivariable generalized estimating equation model.

Results

HIV-infected participants presented significantly incr

SUBMITTER: Morris SR 

PROVIDER: S-EPMC5849030 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature