Cancer-Attributable Mortality Among People With Treated Human Immunodeficiency Virus Infection in North America.

ABSTRACT:

Background

Cancer remains an important cause of morbidity and mortality in people with human immunodeficiency virus (PWHIV) on effective antiretroviral therapy (ART). Estimates of cancer-attributable mortality can inform public health efforts.

Methods

We evaluated 46956 PWHIV receiving ART in North American HIV cohorts (1995-2009). Using information on incident cancers and deaths, we calculated population-attributable fractions (PAFs), estimating the proportion of deaths due to cancer. Calculations were based on proportional hazards models adjusted for age, sex, race, HIV risk group, calendar year, cohort, CD4 count, and viral load.

Results

There were 1997 incident cancers and 8956 deaths during 267145 person-years of follow-up, and 11.9% of decedents had a prior canc

SUBMITTER: Engels EA 

PROVIDER: S-EPMC5849088 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature