Genetic association between a single nucleotide polymorphism in Interleukin-16 (rs4072111) and susceptibility to chronic HCV infection in an Iranian population.

ABSTRACT:

Aim

Our goal was to identify the putative association of rs4072111 variant in IL-16 gene and HCV susceptibility in an Iranian population.

Background

Interleukin 16 (IL-16), a multifunctional cytokine, plays a vital role in modulation of immune system.

Methods

In present case control and cross sectional study, IL-16 gene variant in 300 patients with hepatitis C (HCV) infection and 300 healthy individuals were analyzed. To evaluate this possible association, genomic DNA from venous blood was extracted and genotypes of IL-16 rs4072111 variant were determined by polymerase chain reaction- Fragments Length Polymorphism Technique (PCR-RFLP). Then, rs4072111 C/T genotypes frequency and allelic distribution were evaluated in each group.

Results

The results of genotypin

SUBMITTER: Karkhane M 

PROVIDER: S-EPMC5849117 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature