Single nucleotide polymorphism rs696 in miR449a binding site of NFKBIA gene is correlated with risk of colorectal cancer.

ABSTRACT:

Aim

In present study we have elucidated the role of 2758 A>G (rs696), in the recognition site of miR449a in the 3' UTR of NFKB inhibitor alpha (NFKBIA) gene, in development of sporadic colorectal cancer.

Background

Colorectal cancer (CRC) is rated as second cause of cancer death. Genetic determinants are considered as driving forces in development of sporadic CRC. Single nucleotide polymorphisms (SNPs), are attributed as the main genetic factor in cancers susceptibility. MicroRNAs, are key players in post-translational gene regulation by binding to their specific recognition sequences located at 3' untranslated region (UTR) of mRNAs.

Methods

A case-control study using 143 CRC patients and 137 noncancerous counterparts were undertaken in order to determine rs696 genoty

SUBMITTER: Simonian M 

PROVIDER: S-EPMC5849118 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature