Validation of loci at 2q14.2 and 15q21.3 as risk factors for testicular cancer.

ABSTRACT: Testicular germ cell tumor (TGCT), the most common cancer in men aged 18 to 45 years, has a strong heritable basis. Genome-wide association studies (GWAS) have proposed single nucleotide polymorphisms (SNPs) at a number of loci influencing TGCT risk. To further evaluate the association of recently proposed risk SNPs with TGCT at 2q14.2, 3q26.2, 7q36.3, 10q26.13 and 15q21.3, we analyzed genotype data on 3,206 cases and 7,422 controls. Our analysis provides independent replication of the associations for risk SNPs at 2q14.2 (rs2713206 at P = 3.03 × 10^-2; P-meta = 3.92 × 10-8; nearest gene, TFCP2L1) and rs12912292 at 15q21.3 (P = 7.96 × 10^-11; P-meta = 1.55 × 10^-19; nearest gene PRTG). Case-only analyses did not reveal specific asso

SUBMITTER: Loveday C 

PROVIDER: S-EPMC5849160 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature