Validation of a genetic risk score for atrial fibrillation: A prospective multicenter cohort study.

ABSTRACT:

Background

Atrial fibrillation (AF) is the most commonly encountered arrhythmia and is associated with an elevated risk of stroke. Improving the identification of patients with the highest risk for AF to enable appropriate surveillance and treatment, if necessary, is critical to reducing AF-associated morbidity and mortality. Multiple common single nucleotide polymorphisms (SNPs) are unequivocally associated with the lifetime risk of AF. In the current study we aimed to prospectively validate an AF genetic risk score (GRS) in previously undiagnosed patients at risk for AF.

Methods and findings

Individuals 40 years of age or older with 1 clinical risk factor for AF, presenting with symptoms of AF, or with a first diagnosis of AF, were enrolled for genetic testing and ambulato

SUBMITTER: Muse ED 

PROVIDER: S-EPMC5849279 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature