Advancing chemical risk assessment decision-making with population variability data: challenges and opportunities.

ABSTRACT: Characterizing population variability, including identifying susceptible populations and quantifying their increased susceptibility, is an important aspect of chemical risk assessment, but one that is challenging with traditional experimental models and risk assessment methods. New models and methods to address population variability can be used to advance the human health assessments of chemicals in three key areas. First, with respect to hazard identification, evaluating toxicity using population-based in vitro and in vivo models can potentially reduce both false positive and false negative signals. Second, with respect to evaluating mechanisms of toxicity, enhanced ability to do genetic mapping using these models allows for the identification of key biological pathways and mechanisms th

SUBMITTER: Chiu WA 

PROVIDER: S-EPMC5849521 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature