Overview and systematic review of studies of microbiome in schizophrenia and bipolar disorder.

ABSTRACT: Schizophrenia and bipolar disorder are among the leading causes of disability, morbidity, and mortality worldwide. In addition to being serious mental illnesses, these disorders are associated with considerable systemic physiological dysfunction, including chronic inflammation and elevated oxidative stress. The advent of sophisticated sequencing techniques has led to a growing interest in the potential role of gut microbiota in human health and disease. Advances in this area have transformed our understanding of a number of medical conditions and have generated a new perspective suggesting that gut microbiota might be involved in the development and maintenance of brain/mental health. Animal models have demonstrated strong though indirect evidence for a contributory role of intestinal micr

SUBMITTER: Nguyen TT 

PROVIDER: S-EPMC5849533 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature