Occurrence of marked sepsis-induced immunosuppression in pediatric septic shock: a pilot study.

ABSTRACT:

Background

While the process of sepsis-induced immunosuppression is now well described in adults, very little information is available on immune functions in pediatric sepsis. The current study investigated this in children with septic shock by performing immunomonitoring, including both innate (monocyte human leukocyte antigen-DR, mHLA-DR, expression) and adaptive immunity (lymphocyte subsets count), as well as cytokine concentrations (IL-6, IL-8, IL-10, IL-1Ra, TNF-α, IFN-γ). Subsequent objectives were to assess the associations between inflammatory response, potential immunosuppression and secondary acquired infection occurrence.

Methods

Single-center prospective observational study, including children aged between 1 month and 18 years admitted to pediatric intensive care

SUBMITTER: Remy S 

PROVIDER: S-EPMC5849582 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature