Tissue Phenomics for prognostic biomarker discovery in low- and intermediate-risk prostate cancer.

ABSTRACT: Tissue Phenomics is the discipline of mining tissue images to identify patterns that are related to clinical outcome providing potential prognostic and predictive value. This involves the discovery process from assay development, image analysis, and data mining to the final interpretation and validation of the findings. Importantly, this process is not linear but allows backward steps and optimization loops over multiple sub-processes. We provide a detailed description of the Tissue Phenomics methodology while exemplifying each step on the application of prostate cancer recurrence prediction. In particular, we automatically identified tissue-based biomarkers having significant prognostic value for low- and intermediate-risk prostate cancer patients (Gleason scores 6-7b) after radical prost

SUBMITTER: Harder N 

PROVIDER: S-EPMC5849604 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature