Tailoring light delivery for optogenetics by modal demultiplexing in tapered optical fibers.

ABSTRACT: Optogenetic control of neural activity in deep brain regions ideally requires precise and flexible light delivery with non-invasive devices. To this end, Tapered Optical Fibers (TFs) represent a versatile tool that can deliver light over either large brain volumes or spatially confined sub-regions, while being sensibly smaller than flat-cleaved optical fibers. In this work, we report on the possibility of further extending light emission length along the taper in the range 0.4 mm-3.0 mm by increasing the numerical aperture of the TFs to NA = 0.66. We investigated the dependence between the input angle of light (θ_in) and the output position along the taper, finding that for θ_in > 10° this relationship is linear. This mode-division demultiplexing property of the taper w

SUBMITTER: Pisanello M 

PROVIDER: S-EPMC5849750 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature