A comparison of functional and tractography based networks in cerebral small vessel disease.

ABSTRACT:

Objective

MRI measures of network integrity may be useful disease markers in cerebral small vessel disease (SVD). We compared the sensitivity and reproducibility of MRI derived structural and functional network measures in healthy controls and SVD subjects.

Methods

Diffusion tractography and resting state fMRI were used to create connectivity matrices from 26 subjects with symptomatic MRI confirmed lacunar stroke and 19 controls. Matrices were constructed at multiple scales based on a multi-resolution cortical atlas and at multiple thresholds for the matrix density. Network parameters were calculated over the multiple resolutions and thresholds. In addition the reproducibility of structural and functional network parameters was determined in a subset of the subjects (15 SVD,

SUBMITTER: Lawrence AJ 

PROVIDER: S-EPMC5849860 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature