[¹⁸F]fallypride characterization of striatal and extrastriatal D_2/3 receptors in Parkinson's disease.

ABSTRACT: Parkinson's disease (PD) is characterized by widespread degeneration of monoaminergic (especially dopaminergic) networks, manifesting with a number of both motor and non-motor symptoms. Regional alterations to dopamine D_2/3 receptors in PD patients are documented in striatal and some extrastriatal areas, and medications that target D_2/3 receptors can improve motor and non-motor symptoms. However, data regarding the combined pattern of D_2/3 receptor binding in both striatal and extrastriatal regions in PD are limited. We studied 35 PD patients off-medication and 31 age- and sex-matched healthy controls (HCs) using PET imaging with [¹⁸F]fallypride, a high affinity D_2/3 receptor ligand, to measure striatal and extrastriatal D_2/3

SUBMITTER: Stark AJ 

PROVIDER: S-EPMC5849871 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature