Marijuana Use Impacts Midlife Cardiovascular Events in HIV-Infected Men.

ABSTRACT:

Background

Marijuana use is prevalent among persons infected with human immunodeficiency virus (HIV), but its long-term effects on HIV disease progression and comorbidities are unknown.

Methods

In this prospective study of 558 HIV-infected men enrolled in the Multicenter AIDS Cohort Study between 1990 and 2010, there were 182 HIV seroconverters and 376 with viral suppression on combination antiretroviral therapy (ART). Associations between heavy marijuana use and HIV disease markers or white blood cell (WBC) count were examined using mixed-effects and linear regression models. Effects of marijuana use on cardiovascular (CV) events and other endpoints were estimated using Kaplan-Meier and logistic regression analyses.

Results

The median baseline age of participants was

SUBMITTER: Lorenz DR 

PROVIDER: S-EPMC5850013 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature