Role of Macrophage Socs3 in the Pathogenesis of Aortic Dissection.

ABSTRACT:

Background

Aortic dissection (AD) is a life-threatening medical emergency caused by the abrupt destruction of the intimomedial layer of the aortic walls. Given that previous studies have reported the involvement of proinflammatory cytokine interleukin-6 in AD pathogenesis, we investigated the role of signal transduction and activator of transcription 3 signaling, a downstream pathway of interleukin-6 in macrophages in pathogenesis of AD.

Methods and results

We characterized the pathological and molecular events triggered by aortic stress, which can lead to AD. Aortic stress on the suprarenal aorta because of infrarenal aorta stiffening and angiotensin II infusion for 1 week caused focal medial rupture at the branching point of the celiac trunk and superior mesenteric artery.

SUBMITTER: Ohno-Urabe S 

PROVIDER: S-EPMC5850160 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature