Subclinical Compromise in Cardiac Strain Relates to Lower Cognitive Performances in Older Adults.

ABSTRACT: BACKGROUND:Global longitudinal strain (GLS), reflecting total shortening of the myocardium during the cardiac cycle, has emerged as a more precise myocardial function measure than left ventricular ejection fraction (LVEF). Longitudinal strain may be selectively affected in subclinical heart disease, even in the presence of normal LVEF. This study examines subclinical cardiac dysfunction, assessed by GLS and LVEF, and cognition among older adults. METHODS AND RESULTS:Vanderbilt Memory and Aging Project participants who were free of clinical dementia, stroke, and heart failure (n=318, 73±7 years, 58% male) completed neuropsychological assessment and cardiac magnetic resonance to quantify GLS and LVEF. Linear regression models related GLS and LVEF to neuropsychological performances, adjusting

SUBMITTER: Kresge HA 

PROVIDER: S-EPMC5850190 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature