Age at Menarche and Cardiometabolic Health: A Sibling Analysis in the Scottish Family Health Study.

ABSTRACT:

Background

Previous studies of age at menarche and cardiometabolic health report conflicting findings, and only a few could account for childhood characteristics. We aimed to estimate the associations of age at menarche with cardiovascular risk factors in unrelated women and within sister groups, under the assumption that within-sibship estimates will be better adjusted for shared genetics and early life environment.

Methods and results

Our study included 7770 women, from 5984 sibships, participating in the GS:SFHS (Generation Scotland: Scottish Family Health Study). We used fixed- and between-effects linear regression to estimate the associations within sister groups and between unrelated individuals, respectively. Within sibships, the mean difference between sisters with e

SUBMITTER: Magnus MC 

PROVIDER: S-EPMC5850196 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature