New concepts for an old problem: the diagnosis of endometrial hyperplasia.

ABSTRACT:

Background

Endometrial hyperplasia (EH) is a uterine pathology representing a spectrum of morphological endometrial alterations. It is predominantly characterized by an increase in the endometrial gland-to-stroma ratio when compared to normal proliferative endometrium. The clinical significance of EH lies in the associated risk of progression to endometrioid endometrial cancer (EC) and 'atypical' forms of EH are regarded as premalignant lesions. Traditional histopathological classification systems for EH exhibit wide and varying degrees of diagnostic reproducibility and, as a consequence, standardized patient management can be challenging.

Objective and rationale

EC is the most common gynaecological malignancy in developed countries. The incidence of EC is rising, with alarm

SUBMITTER: Sanderson PA 

PROVIDER: S-EPMC5850217 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature