DNA methylation signatures in cord blood of ICSI children.

ABSTRACT:

Study question

Does ICSI induce specific DNA methylation changes in the resulting offspring?

Summary answer

Although several thousand analyzed CpG sites (throughout the genome) displayed significant between-group methylation differences, both ICSI and spontaneously conceived children varied within the normal range of methylation variation.

What is known already

Children conceived by ART have increased risks for medical problems at birth and to the extent of present knowledge also in later life (i.e. impaired metabolic and cardiovascular functions). One plausible mechanism mediating these ART effects are epigenetic changes originating in the germ cells and/or early embryos and persisting during further development.

Study design, size, duration

We compared the co

SUBMITTER: El Hajj N 

PROVIDER: S-EPMC5850272 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature