Complex CatSper-dependent and independent [Ca2+]i signalling in human spermatozoa induced by follicular fluid.

ABSTRACT:

Study question

Does progesterone in human follicular fluid (hFF) activate CatSper and do other components of hFF modulate this effect and/or contribute separately to hFF-induced Ca2+ signaling?

Summary answer

hFF potently stimulates CatSper and increases [Ca2+]i, primarily due to high concentrations of progesterone, however, other components of hFF also contribute to [Ca2+]i signaling, including modulation of CatSper channel activity and inhibition of [Ca2+]i oscillations.

What is known already

CatSper, the principal Ca2+ channel in spermatozoa, is progesterone-sensitive and essential for fertility. Both hFF and progesterone, which is present in hFF, influence sperm function and increase their [Ca2+]i.

Study design, size, duration

This basic medical research st

SUBMITTER: Brown SG 

PROVIDER: S-EPMC5850303 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature