Oncotargeting by Vesicular Stomatitis Virus (VSV): Advances in Cancer Therapy.

ABSTRACT: Modern oncotherapy approaches are based on inducing controlled apoptosis in tumor cells. Although a number of apoptosis-induction approaches are available, site-specific delivery of therapeutic agents still remain the biggest hurdle in achieving the desired cancer treatment benefit. Additionally, systemic treatment-induced toxicity remains a major limiting factor in chemotherapy. To specifically address drug-accessibility and chemotherapy side effects, oncolytic virotherapy (OV) has emerged as a novel cancer treatment alternative. In OV, recombinant viruses with higher replication capacity and stronger lytic properties are being considered for tumor cell-targeting and subsequent cell lysing. Successful application of OVs lies in achieving strict tumor-specific tropism called oncotropism, w

SUBMITTER: Bishnoi S 

PROVIDER: S-EPMC5850397 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature