Pharmacological Inhibition of Protein Kinase C Reduces West Nile Virus Replication.

ABSTRACT: Flaviviruses are relevant animal and human pathogens that include West Nile virus (WNV), Japanese encephalitis virus, dengue virus, or Zika virus, among others. Currently, no licensed therapy is available to fight flaviviral infections. Protein kinases C (PKCs) constitute a family of multifunctional lipid-dependent isoenzymes that regulate a wide variety of cellular processes (apoptosis, differentiation, proliferation, cellular transformation, motility, adhesion, etc.) being currently considered at the front line of drug development for the treatment of diverse human disorders. PKCs have also been implicated in different steps during viral replication; however, nowadays, results regarding their role in flavivirus replication are controversial. Here we demonstrate that calphostin C and chel

SUBMITTER: Blazquez AB 

PROVIDER: S-EPMC5850398 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature